THE ULTIMATE GUIDE TO NR1-SITE

Applying this approach, Kalbaugh et al. assigned affinity and efficacy roles to positions from the LBDs with the NR1 and NR2A NMDAR subunits. In situ mutation of residues in immediate contact with certain ligand afflicted each efficacy and affinity, when positions that stabilize the closed cleft conformation and not using a immediate ligand convers